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KMID : 0545120100200081189
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 8 p.1189 ~ p.1191
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Hydoroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus.
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Ryoo In-Ja
Yun Bong-Sik
Lee In-Kyoung
Kim Young-Hee
Lee Ik-Soo
Ahn Jong-Seok
Bae Ki-Hwan
Yoo Ick-Dong
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Abstract
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In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.
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KEYWORD
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Hibiscus syriacus, hydroxyhibiscon A, human neutrophil elastase
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